Publications by authors named "L M Scorr"
Prevalence and clinical features of cervical dystonia in Parkinson's disease.
Parkinsonism Relat Disord
October 2024
Article Synopsis
- The study aimed to determine how common cervical dystonia (CD) is among patients with Parkinson's disease (PD) and to identify its clinical features.
- Out of 301 PD patients examined, 28 (9.3%) were found to have CD, which is significantly higher than what's typically seen in the general population, highlighting that CD is more common in PD cases.
- The characteristics of CD-PD differ from idiopathic cervical dystonia (ICD) patients in terms of gender, age, severity, and response to medication, suggesting the need for more extensive research to explore these differences further.
Background: Prior studies have indicated that female individuals outnumber male individuals for certain types of dystonia. Few studies have addressed factors impacting these sex differences or their potential biological mechanisms.
Objectives: To evaluate factors underlying sex differences in the dystonias and explore potential mechanisms for these differences.
Background: Although there are many possible causes for cervical dystonia (CD), a specific etiology cannot be identified in most cases. Prior studies have suggested a relationship between autoimmune disease and some cases of CD, pointing to possible immunological mechanisms.
Objective: The goal was to explore the potential role of multiple different immunological mechanisms in CD.
Background: Blepharospasm is treated with botulinum toxin, but obtaining satisfactory results is sometimes challenging.
Objective: The aim is to conduct an exploratory trial of oral dipraglurant for blepharospasm.
Methods: This study was an exploratory, phase 2a, randomized, double-blind, placebo-controlled trial of 15 participants who were assigned to receive a placebo or dipraglurant (50 or 100 mg) and assessed over 2 days, 1 and 2 hours following dosing.