A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation.

Background: C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune cell activation via unknown molecular mechanisms.

Results: In a multi-translational study of systemic inflammation, we found a time- and inflammation-dependent pCRP dissociation into mCRP.

Dietary patterns, inflammatory biomarkers and cognition in older adults: An analysis of three population-based cohorts.

Background: Targeting effective strategies to prevent cognitive decline is key in the aging population. Some diets have been linked to a slower cognitive decline, potentially through reducing inflammation. We aimed at determining the effect of inflammatory dietary patterns (IDPs) on cognitive function in three population-based cohorts.

Advancing Digital Health Equity: An Interdisciplinary Educational Approach to Digital Health Access and Inclusivity.

The innovatively structured BCIT Digital Health program is designed to build digital-care capacity within the healthcare workforce to improve outcomes across healthcare communities and optimize clinical transformation. An equity-oriented focus and an active commitment to reducing health disparities puts the patient voice at the centre of the program. To improve accessibility in digital health, the program focuses on inclusivity strategies such as capacity building, Indigenous perspectives, equity-oriented care and providing training to build an effective digital healthcare system.