Publications by authors named "L M Sargent"
Introduction: Little is known regarding the relationship between anticholinergic medications and frailty in dementia with Lewy bodies (DLB).
Methods: Anticholinergic Cognitive Burden Scale (ACB) and Claims-based Frailty Index scores were calculated for 12 months prior to the dementia diagnosis using electronic medical record and claims data. Logistic regression was used to estimate the association between ACB and odds of frailty.
Article Synopsis
- - The study investigated the relationship between rest-activity rhythms (RAR) and frailty in older adults, analyzing data from 2,531 participants aged 60 and above, while also considering differences by sex.
- - Results indicated that frail and pre-frail individuals showed poorer RAR metrics, such as lower relative amplitude and higher variability, particularly highlighting a stronger association in females compared to males.
- - The findings suggest that diminished RAR strength is linked to increased frailty, especially in women, indicating that monitoring RAR could be useful for assessing frailty, but more research is needed to explore this connection over time.
Article Synopsis
- - The paper explores using Large Language Models (LLMs) to streamline data wrangling and automate tasks in data discovery and harmonization, crucial for making biomedical data AI-ready by developing Common Data Elements (CDEs).
- - A human-in-the-loop approach was utilized to ensure the accuracy of generated CDEs from various studies and databases, achieving a high accuracy rate where 94.0% of fields required no manual changes, with an interoperability mapping rate of 32.4%.
- - The resulting CDEs are designed to improve dataset compatibility by measuring how well different data sources align with these standards, ultimately enhancing the efficiency and scalability of biomedical research efforts.
The lack of diversity in genomic studies is a disparity that influences our understanding of human genomic variation and threatens equity in the benefits of precision medicine. Given our current genomic research with Black older adults, we conducted a qualitative study to elucidate participants' knowledge, attitudes, and beliefs about genomic research and research participation and what factors contribute to their willingness to participate and to gain insights into barriers that researchers may have in recruiting Black Americans. We conducted semistructured interviews (N=16) with previous genomic research participants, and an inductive thematic approach was used to code and interpret the data.
View Article and Find Full Text PDFIn the lung, carcinogenesis is a multi-stage process that includes initiation by a genotoxic agent, promotion that expands the population of cells with damaged DNA to form a tumor, and progression from benign to malignant neoplasms. We have previously shown that Mitsui-7, a long and rigid multi-walled carbon nanotube (MWCNT), promotes pulmonary carcinogenesis in a mouse model. To investigate the potential exposure threshold and dose-response for tumor promotion by this MWCNT, 3-methylcholanthrene (MC) initiated (10 μg/g, i.
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