Publications by authors named "L M Sanford"
Article Synopsis
- The study investigates sleep patterns via polysomnography in patients with obsessive-compulsive disorder (OCD) compared to healthy individuals.
- Significant findings show that OCD patients experience less sleep efficiency and total sleep time, along with altered REM sleep characteristics.
- The research suggests these sleep abnormalities highlight the importance of thorough sleep assessments for people with OCD.
Article Synopsis
- Long-duration space missions to the Moon and Mars pose significant physical and mental health challenges for astronauts due to exposure to multiple stressors, particularly space radiation (SR) and sleep disturbances.
- Ground-based studies indicate that both SR and poor sleep quality can impair cognitive performance, particularly in complex tasks like the attentional set-shifting task (ATSET).
- This research found that fragmented sleep significantly worsened ATSET performance in rats previously exposed to galactic cosmic ray simulation (GCRsim), revealing that sleep disturbance can amplify cognitive deficits caused by SR, with variations noted between male and female rats in the type of performance decrements.
Cellular zinc status alters chromatin accessibility and binding of p53 to DNA.
Life Sci Alliance
September 2024
Zn is an essential metal required by approximately 850 human transcription factors. How these proteins acquire their essential Zn cofactor and whether they are sensitive to changes in the labile Zn pool in cells remain open questions. Using ATAC-seq to profile regions of accessible chromatin coupled with transcription factor enrichment analysis, we examined how increases and decreases in the labile zinc pool affect chromatin accessibility and transcription factor enrichment.
View Article and Find Full Text PDFSerine protease inhibitors are a superfamily of proteins that regulate various physiological processes including fibrinolysis, inflammation and immune responses. In parasite systems, serpins are believed to play important roles in parasite colonization, inhibition of host immune serine proteases and penetration of defensive barriers. However, serpins are less well characterized in schistosomes.
View Article and Find Full Text PDFDiphyllin is a naturally occurring lignan comprised of an aryl naphthalene lactone scaffold that demonstrates beneficial biological activities in disease models of cancer, obesity, and viral infection. A target of diphyllin and naturally occurring derivatives is the vacuolar ATPase (V-ATPase) complex. Although diphyllin-related natural products are active with in vitro models for viral entry, the potencies and unknown pharmacokinetic properties limit well-designed in vivo evaluations.
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