Publications by authors named "L M Sanchez-Gomez"
To assess the efficacy of electrical impedance tomography (EIT)-guided positive end-expiratory pressure (PEEP) titration in improving outcomes for patients with acute respiratory distress syndrome (ARDS). A systematic review and meta-analysis was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Randomized controlled trials and observational studies with a control group comparing EIT-guided PEEP titration to other strategies were included.
View Article and Find Full Text PDFEarly antibiotic de-escalation in patients with severe infections due to bloodstream infection by enterobacterales: A post hoc analysis of a prospective multicentre cohort.
Int J Antimicrob Agents
November 2024
Background: Data about antibiotic de-escalation in sepsis associated with the bloodstream and caused by Enterobacterales are scarce. The objectives of this study are to identify factors associated with early de-escalation and to analyse the impact of de-escalation on mortality in patients with Enterobacterales bloodstream infection (BSI) with a Sequential Organ Failure Assessment (SOFA) score ≥ 2.
Methods: A prospective, multicentre cohort study was performed including episodes of BSI due to Enterobacterales and a SOFA score ≥ 2 who were receiving an active antipseudomonal β-lactam; the isolate should be susceptible to at least 1 narrower-spectrum antibiotic.
Objectives: Bloodstream infections (BSI) are an important cause of mortality, although they show heterogeneity depending on patients and aetiological factors. Comprehensive and specific mortality scores for BSI are scarce. The objective of this study was to develop a mortality predictive score in BSI based on a multicentre prospective cohort.
View Article and Find Full Text PDFArticle Synopsis
- The report documents the first case of high-grade resistance to integrase strand transfer inhibitors (INSTIs) in an HIV patient treated with the coformulated medication bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF), specifically highlighting mutations E157Q and R263K.
- A heavily treatment-experienced patient, who switched to BIC/FTC/TAF due to drug interactions and had poor adherence, experienced virological failure after months on the new treatment, leading to the discovery of multiple genetic mutations.
- The findings emphasize the potential for rare resistance mutations to develop in patients with poor adherence to prescribed regimens and suggest caution when switching patients from first-generation
Background: Robotic surgery (RS) may offer benefits compared with freehand/conventional surgery (FS) in the treatment of patients with spinal disease. The aim of this study was to evaluate the efficacy and safety of RS versus FS in spinal fusion.
Methods: A systematic review and meta-analysis was performed.