[Streptonigron--a minor component of bruneomycin complex].

A mutant strain of the bruneomycin-producing culture which produced up to 10% of the minor component was selected. The component was identified as streptonigrone. It was isolated and its physicochemical properties and antibacterial activity were investigated.

[Determination of carminomycin in its preparations by high-performance liquid chromatography].

A three component system for separating a mixture of carminomycin, carminomycinone and 13-dihydrocarminomycinone by HPLC was developed. Spherisorb ODS Column, 4.6 X 250 mm, the particle size of 10 micron was used.

[Physicochemical properties of octamycin].

Octamycin, an original polyenic antibiotic was developed. The antibiotic is of an amphoteric character. The number and nature of the functional groups were determined by potentiometric titration.

[Quantitative determination of the antibiotic doxorubicin by high-performance liquid chromatography].

A new three-component system was developed for separation of a mixture containing 6 components: doxorubicin, rubomycin, dihydrorubomycin, 14-bromrubomycin, doxorubicinone and rubomycinone. The system uses reverse phase high performance liquid chromatography. Separation was performed on a column with Spherisorb C18 (4.

[Structure of the antibiotic virenomycin].

To identify the structure of virenomycin, a new antitumor antibiotic consisting of components V and M, its acetyl and permethyl derivatives, as well as products of acid methanolysis and their derivatives were obtained. The IR-, NMR- and mass-spectra of the above compounds are presented. Based on an analysis of the spectral data the structure of virenomycin is suggested.