Publications by authors named "L M Roesner"
Background: T2 cells crucially contribute to the pathogenesis of atopic dermatitis (AD) by secreting high levels of IL-13 and IL-22. Yet the upstream regulators that activate T2 cells in AD skin remain unclear. IL-18 is a putative upstream regulator of T2 cells because it is implicated in AD pathogenesis and has the capacity to activate T cells.
View Article and Find Full Text PDFThe number of older adults worldwide is growing exponentially. However, while living longer, older individuals are more susceptible to both non-infectious and infectious diseases, at least in part due to alterations of the immune system. Here, we report on a prospective cohort study investigating the influence of age on immune responses and susceptibility to infection.
View Article and Find Full Text PDFBackground: Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease with skin barrier defects and a misdirected type 2 immune response against harmless antigens. The skin microbiome in AD is characterized by a reduction in microbial diversity with a dominance of staphylococci, including ().
Objective: To assess whether antigens play a role in AD, we screened for candidate allergens and studied the T cell and humoral immune response against the extracellular serine protease (Esp).
Article Synopsis
- * Researchers analyzed cytokine production before and after antibiotic treatment in over 1,000 patients, discovering a negative relationship between antibody production and IL-10 levels, as well as increased IL-1Ra in those with advanced disease.
- * Genome-wide mapping identified 34 cytokine quantitative trait loci (cQTLs), including 31 new ones, linking immune responses to Lyme borreliosis susceptibility and offering insights relevant to other immune-related diseases.