Publications by authors named "L M Rodriguez-Lorenzo"

Article Synopsis
  • This study examines how different amounts of hydroxyapatite (OHAp) and gelatin affect the crosslinking time and shear stress experienced by human dermal fibroblasts in alginate-based bioinks, which are important for 3D bioprinting.
  • Four bioink formulations were created with a mix of alginate and gelatin and various concentrations of OHAp, showing that higher OHAp levels improved the bioinks' properties like viscosity and elasticity.
  • Tests showed that fibroblasts had less than 1.54 Pa of shear stress during printing, and over 70% cell viability was maintained after 24 hours, with 92% viability after a week with the highest OHAp concentration, indicating these bioinks
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The biological response to nanomaterials exposure depends on their properties, route of exposure, or model organism. Titanium dioxide nanoparticles (TiO NPs) are among the most used nanomaterials; however, concerns related to oxidative stress and metabolic effects resulting from their ingestion are rising. Therefore, in the present work, we addressed the metabolic effects of citrate-coated 45 nm TiO NPs combining bioaccumulation, tissue ultrastructure, and proteomics approaches on gilthead seabream, Sparus aurata and Japanese carpet shell, Ruditapes philippinarum.

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Seaweeds are recognised as a potential eco-friendly food source. However, some species have shown the capacity to bioaccumulate many substances of diverse nature, such as inorganic nanoparticles (NPs), which may have potentially harmful effects on them. Among these NPs, silver nanoparticles (AgNPs) have been used to enhance the antifungal and antibacterial properties of the final consumer products, such as textiles and food packages.

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Bone tissue regeneration strategies have incorporated the use of natural polymers, such as hydroxyapatite (nHA), chitosan (CH), gelatin (GEL), or alginate (ALG). Additionally, platelet concentrates, such as platelet-rich fibrin (PRF) have been suggested to improve scaffold biocompatibility. This study aimed to develop scaffolds composed of nHA, GEL, and CH, with or without ALG and lyophilized PRF, to evaluate the scaffold's properties, growth factor release, and dental pulp stem cells (DPSC), and osteoblast (OB) derived from DPSC viability.

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