Publications by authors named "L M Rocha-Ramirez"

Article Synopsis
  • In vitro and in vivo studies indicate that TNF-α, a pro-inflammatory cytokine, is linked to poor cancer prognosis, prompting evaluation of its genetic variations and serum levels in Mexican neuroblastoma (NB) patients.
  • Analysis of specific TNF-α genetic polymorphisms (-308 G>A and -238 G>A) revealed significant differences between NB patients and healthy controls, with certain genotypes being associated with decreased risk or susceptibility to NB and unfavorable tumor characteristics.
  • Findings suggest that the rs1800629 AA genotype may increase susceptibility to NB and correlate with poorer prognosis, emphasizing the need for further research to validate these associations on a larger scale.
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Urinary tract infections (UTIs) represent a clinical and epidemiological problem of worldwide impact that affects the economy and the emotional state of the patient. Control of the condition is complicated due to multidrug resistance of pathogens associated with the disease. Considering the difficulty in carrying out effective treatment with antimicrobials, it is necessary to propose alternatives that improve the clinical status of the patients.

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Article Synopsis
  • Overuse of antimicrobials has led to the rise of multidrug-resistant bacteria, complicating the treatment of infections like urinary tract infections (UTIs).
  • Autologous bacterial lysates show promise as an alternative treatment for UTIs, but producing individual immunogens can be costly.
  • A study on a polyvalent bacterial lysate containing 10 serotypes demonstrated safety in cell cultures and animals, while effectively stimulating the immune response, suggesting it could help manage chronic UTIs and reduce antimicrobial usage.
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The parasite is the etiologic agent of trichomoniasis, the most common non-viral sexually transmitted disease worldwide. This infection often remains asymptomatic and is related to several health complications. The traditional treatment for trichomoniasis is the use of drugs of the 5-nitroimidazole family, such as metronidazole; however, scientific reports indicate an increasing number of drug-resistant strains.

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Worldwide, Urinary Tract Infections (UTIs) are an important health problem with many cases reported annually, women being the most affected. UTIs are relevant because they can become a recurrent condition, associated with different factors that contribute to the chronicity of the disease (cUTI). cUTI can be classified as persistent (peUTI) when the causative agent is the same each time the infection occurs or as reinfection (reUTI) when the associated microorganism is different.

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