Publications by authors named "L M R Silla"
Article Synopsis
- Natural killer (NK) cells are a type of innate immune cell that respond to virus-infected or cancerous cells without prior exposure, helping to develop long-lasting immunity.
- In stem cell transplants, NK cells are vital for fighting against leukemia due to their graft versus leukemia effect and their predominantly regulatory role in tissues.
- Current research focuses on the effectiveness of using non-genetically modified NK cells for treating relapsed or refractory acute leukemia, indicating that the persistence and expansion of donor cells in peripheral blood do not necessarily correlate with successful anti-leukemia activity.
Introduction: The Coronavirus Disease 2019 (COVID-19) pandemic highlighted the importance of understanding patients' goals, values, and medical care preferences given the high morbidity and mortality. We aimed to examine rates of advance care planning (ACP) documentation along with hospital course differences in the absence or presence of ACP among hospitalized patients with COVID-19.
Methods: This retrospective cohort study was performed at a single tertiary academic medical center.
Following health agencies warning, the use of animal origin supplements should be avoided in biological products proposed as therapy in humans. Platelet lysate and several other growth factors sources are alternatives to replace fetal calf serum, the current gold standard in clinical-grade cell culture. However, the platelet supplement's content lacks data due to different production methods.
View Article and Find Full Text PDFObjective: To assess patient experiences with rapid implementation of ambulatory telehealth during the coronavirus disease 2019 (COVID-19) pandemic.
Methods: A mixed-methods study was performed to characterize the patients' experience with neurology telehealth visits during the first 8 weeks of the COVID-19 response. Consecutive patients who completed a telehealth visit were contacted by telephone.
Patients with acute myeloid leukaemia (AML) have a five-year survival rate of 28·7%. Natural killer (NK)-cell have anti-leukaemic activity. Here, we report on a series of 13 patients with high-risk R/R AML, treated with repeated infusions of double-bright (CD56 /CD16 ) expanded NK cells at an academic centre in Brazil.
View Article and Find Full Text PDF