Publications by authors named "L M Polo"
Article Synopsis
- The study highlights challenges in diagnosing sarcopenia among hemodialysis patients due to differing definitions from the EWGSOP2 and SDOC consensuses.
- Similar prevalence rates for sarcopenia were found using both definitions, but there was a weak overall agreement in diagnoses between the two methods.
- The results suggest that while there is some alignment in identifying severe sarcopenia cases, the discrepancies in diagnosing low muscle strength indicate a need for standardized approaches in clinical settings.
Objectives: The use of ventricular assist devices (VADs) in children is increasing. However, absolute numbers in individual centres and countries remain small. Collaborative efforts such as the Paedi-European Registry for Patients with Mechanical Circulatory Support (EUROMACS) are therefore essential for combining international experience with paediatric VADs.
View Article and Find Full Text PDFBotulinum neurotoxins (BoNTs) are valuable tools to unveil molecular mechanisms of exocytosis in neuronal and non-neuronal cells due to their peptidase activity on exocytic isoforms of SNARE proteins. They are produced by Clostridia as single-chain polypeptides that are proteolytically cleaved into light, catalytic domains covalently linked via disulfide bonds to heavy, targeting domains. This format of two subunits linked by disulfide bonds is required for the full neurotoxicity of BoNTs.
View Article and Find Full Text PDFMembrane fusion is a crucial mechanism in a wide variety of important events in cell biology from viral infection to exocytosis. However, despite many efforts and much progress, cell-cell fusion has remained elusive to our understanding. Along the life of the fusion pore, large conformational changes take place from the initial lipid bilayer bending, passing through the hemifusion intermediates, and ending with the formation of the first nascent fusion pore.
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