Derivatization of 2,1,3-Benzothiadiazole via Regioselective C-H Functionalization and Aryne Reactivity.

Despite growing interest in 2,1,3-benzothiadiazole (BTD) as an integral component of many functional molecules, methods for the functionalization of its benzenoid ring have remained limited, and many even simply decorated BTDs have required synthesis. We show that regioselective Ir-catalyzed C-H borylation allows access to versatile 5-boryl or 4,6-diboryl BTD building blocks, which undergo functionalization at the C4, C5, C6, and C7 positions. The optimization and regioselectivity of C-H borylation are discussed.

Access to long-lived room temperature phosphorescence through auration of 2,1,3-benzothiadiazole.

A series of 2,1,3-benzothiadiazole-Au(I)-L complexes have been synthesised, structurally characterised and investigated for their photophysical properties. These are the first organometallic Au(I) complexes containing a C-Au bond on the highly electron-deficient benzothiadiazole unit. The complexes exhibit solution-phase phosphorescence at room temperature, assigned to the intrinsic triplet state of the benzothiadiazole unit that is efficently populated through its attachment to gold.

Synthesis and crystal structures of boryl -silylaryl tri-fluoro-methane-sulfonates.

We report the synthesis and structural characterization of three crystalline borylated -silylaryl tri-fluoro-methane-sulfonates: 5-(4,4,5,5-tetra-methyl-1,3,2-dioxaborolan-2-yl)-2-(tri-methyl-sil-yl)phenyl tri-fluoro-methane-sulfonate, CHBFOSSi (), 4-(4,4,5,5-tetra-methyl-1,3,2-dioxaborolan-2-yl)-2-(tri-methyl-sil-yl)phenyl tri-fluoro-methane-sulfonate, CHBFOSSi (), and 2-methyl-4-(4,4,5,5-tetra-methyl-1,3,2-dioxaborolan-2-yl)-6-(tri-methyl-silyl)phen-yl tri-fluoro-methane-sulfonate, CHBFOSSi (), which are versatile aryne precursors. For all three compounds, the heteroatom substituents are almost coplanar with the central aromatic moiety. C-heteroatom bonding metrics are unexceptional and fall withing the typical range of C-B, C-Si, and C-O single bonds.

Association of Serum Vaspin Concentration with Metabolic Disorders in Obese Individuals.

Vaspin, a molecule produced in visceral adipose tissue, seems to participate in the pathogenesis of metabolic disorders. The study aimed to determine the association of vaspin concentration with metabolic disorders in obese individuals. Forty obese patients and twenty normal-weight subjects underwent biochemical (fasting glucose, insulin, lipid profile, interleukin-6, hs-CRP, vaspin concentration), blood pressure, and anthropometric measurements.