[Effect of semicarbazide on the peroxidation processes and Lewis carcinoma growth in mice].

Effects of various doses of semicarbazide on Lewis carcinoma metastasing and peroxidation processes in C57B1 mice have been investigated. In the animals with inoculated Lewis carcinoma, the semicarbazide in the dose of 1/120 LD50 had practical influence on the tumour growth and inhibited the metastasing into mice lungs (P < 0.05).

[Altered collagene characteristics and lysyl oxidase activity in lathyrism].

Experiments were carried out on rats with lathyrism, which was induced by adding semicarbazide (0.075%) into drinking water for 45 days. The data obtained show a 30% reduction in the body weight and an increase in.

[Formaldehyde metabolism in semicarbazide intoxication].

Subchronic administration of semicarbazide in the experiment with the rats was used to reduce the formaldehyde level in the organism in order to reveal the interaction between formaldehyde metabolism and biochemical parameters, which define the oxidant-antioxidant system condition and NO metabolism. It has been found that under semicarbazide impact the generation of free radicals, ROS, nitrite and nitrate were enhanced while aldehydes level was reduced that resulted from not only semicarbazide effect like the aldehydes acceptor, but the formaldehyde synthesis slowdown and acceleration of its transformation into format as well. We suppose that formaldehyde plays certain role in the development of connective tissue pathology.

[Characteristics of nitrogen metabolism in chickens with gout].

It is shown that the intensity of ammonium genesis, purines biosynthesis and redox processes increases in the organism of chicken with visceral gout. Sodium bicarbonate-correction of the acid-alkaline state of chickens is performed in order to normalize disturbances observed under gout.

[State of acid-base balance in chickens and pigs in commercial livestock farms].

Experiments on chickens of different age groups (one day--1 months) from large poultry plants of the Kiev Region established that metabolic acidosis develops in chickens at the age of 10-30 days. Compensated alkalosis is observed in them at the age of two months and further. In chickens whose HCO3- level in blood is 15-18 mM/l the content of uric acid in the liver and blood increases as compared to the control (HCO3- --23 mM/l); they also differ in a high intensity of the growth.