Publications by authors named "L M Perrem"
For decades spirometry has been the benchmark test for capturing lung function in children but its recognized limitations required the development of other techniques. This article introduces novel techniques in lung function assessment for pediatric patients, including multiple breath washout, impulse oscillometry, structured light plethysmography, and electrical impedance tomography, and common themes in interpreting the results. Challenges include standardization, reference data, and clinical integration of these innovative tools.
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- Elevated inflammation markers in cystic fibrosis (CF) patients can hinder lung function recovery after exacerbations; the study aimed to see if oral prednisone could help patients who weren’t improving with antibiotics.
- A randomized trial with 173 CF patients tested the effectiveness of prednisone against a placebo after 7 days of antibiotic treatment, measuring recovery of lung function (FEV).
- The results showed no significant difference in lung function recovery between the prednisone group (50% recovery) and the placebo group (39%), suggesting prednisone does not provide additional benefits for these patients.*
Background: Short palate, lung, and nasal epithelium clone 1 (SPLUNC1) is an innate defence protein that acts as an anti-microbial agent and regulates airway surface liquid volume through inhibition of the epithelial sodium channel (ENaC). SPLUNC1 levels were found to be reduced in airway secretions of adults with cystic fibrosis (CF). The potential of SPLUNC1 as a biomarker in children with CF is unknown.
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- - This paper is part of a series updating standards of care for cystic fibrosis (CF), emphasizing the importance of recognizing and managing various CF health issues despite advancements like CFTR modulators.
- - It highlights the need for multidisciplinary care to address ongoing extrapulmonary issues such as diabetes, liver disease, and increased cancer risk, which require regular screenings.
- - Mental and emotional support is crucial for individuals with CF and their families, especially during challenging times, and planning for end-of-life care should be approached with sensitivity and compassion.