Publications by authors named "L M Perin"

Background: Breast augmentation remains a leading cosmetic surgical procedure. Over the past two decades, various benefits and complications of pocket selection techniques have been described for breast augmentations. However, there has been limited evolution in the dissection technique sequence initially described by Tebbetts in his seminal publication.

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Total hepatectomy and liver transplantation have emerged as a game-changing strategy in the treatment of several liver-confined primary or metastatic tumors, opening a new era of transplant oncology. However, the expansion of indications is going to worsen the chronic scarcity of organs, and new strategies are needed to enlarge the donor pool. A possible source of organs could be developing split liver transplantation programs.

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Article Synopsis
  • - Fasting-mimicking diets (FMD), specifically a low-salt version (LS-FMD), were tested in rats with kidney damage and were found to restore normal kidney function and structure by inducing a nephrogenic gene program.
  • - LS-FMD activated pathways that promote cell reprogramming in the kidney, specifically targeting podocytes, which play a critical role in kidney health.
  • - A pilot study in patients with chronic kidney disease showed that FMD cycles improved kidney function and reduced protein levels in urine, indicating potential for further research in treating progressive kidney diseases.
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  • Personalized disease models are essential for testing treatments on diseased cells, particularly innovative therapies, and this study focuses on extracellular vesicles (EVs) from kidney progenitor cells (nKPCs) as a potential treatment for steroid-resistant nephrotic syndrome in children.
  • Urinary podocytes from affected patients were treated with nKPC-EVs and compared to standard drugs, showing that nKPC-EVs significantly reduced permeability in podocytes, while standard treatments had limited effectiveness.
  • RNA sequencing identified the upregulation of two genes, SUMO1 and SENP2, linked to the treatment's effectiveness, suggesting that the SUMOylation pathway plays a crucial role in the therapeutic impact of nKPC-EVs
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