Publications by authors named "L M Owen"

The imperative to improve the well-being of graduate medical education (GME) trainees has been well documented. While existing interventions have largely centered on increasing individual trainee resilience, less focus has been on the role of national health policy, economics, and the overall U.S.

View Article and Find Full Text PDF

The Antarctic Circumpolar Current (ACC) dominates the transfer of heat, salt, and tracers around the Southern Ocean (SO), driving the upwelling of carbon-rich deep waters around Antarctica. Paleoclimate reconstructions reveal marked variability in SO circulation; however, few records exist coupling quantitative reconstructions of ACC flow with tracers of SO upwelling spanning multiple Pleistocene glacial cycles. Here, we reconstruct near-bottom flow speed variability in the SO south of Africa, revealing systematic glacial-interglacial variations in the strength and/or proximity of ACC jets.

View Article and Find Full Text PDF

Percutaneous cystolithotomy (PCCL) is a minimally-invasive technique for removal of cystoliths. There is currently no information regarding optimum patient positioning during PCCL. The objective of this study was to assess whether patient positioning affected ease of cystolith retrieval via PCCL.

View Article and Find Full Text PDF
Article Synopsis
  • - The study evaluates if major management guidelines for extremely preterm infants are effectively applicable to those born before 25 weeks' gestation by reviewing three significant sets of guidelines and their referenced studies.
  • - Out of 519 studies analyzed, only about 14.5% of infants were under 25 weeks, with a significant portion of the research, 37.8%, not including any infants from this critical group.
  • - The findings conclude that infants born before 25 weeks gestation are underrepresented in the data driving clinical guidelines, highlighting the need for more focused research on this vulnerable population.
View Article and Find Full Text PDF
Article Synopsis
  • Bulk deconvolution using single-cell RNA-seq is important for analyzing complex biological samples, but differences in sequencing technology can lead to inaccuracies.
  • The researchers created a new framework called DeMixSC that improves deconvolution by utilizing well-matched benchmark datasets to account for these technological discrepancies.
  • DeMixSC was tested on datasets from healthy retinas and ovarian cancer tissues, showing improved accuracy and the ability to reveal significant biological differences in patient groups, highlighting its usefulness in clinical applications.
View Article and Find Full Text PDF