[Age-dependent changes in phospholipid content and neutral lipid contents in aging].

Oxidative processes and lipid metabolism in young (3-4 months) and old (25-28 months) were studied. The increase of the rate of reactions of free radical oxidation of lipids (hydroperoxides, and malondialdehyde) and the accumulation of products of oxidative modification of proteins was recorded in mitochondrial fraction of rat brain. The accumulation of nitric oxide in the mitochondria and the oxidation products leads to the development of oxidative stress.

[Effect of cysteine lithium salt on lipid peroxidation in the model of dopaminergic system disorder].

The antioxidant activity of a newly synthesized compound, cysteine lithium salt, was discovered using methyl oleate oxidation model of dopaminergic system disorder. Experimental data show that injection of the synthesized compound in animals with experimentally induced L-DOPA brings to normalization effect conditioned by inhibiting free radical reactions in the nuclear and mitochondrial fractions of brain cells. Antioxidant effect of the synthesized compound is related to its chemical structure that contains cysteine--an agent involved in the biosynthesis of glutathione, which is a component of glutathione peroxidase and glutathione reductase enzymes participating in the antiradical protection system.

[Neutral and acid glycolipids in the brain in the presence of ischemia and during antioxidant treatment].

The content of lipid peroxidation products and the metabolism of gangliosides and galactosylceramides in brain tissue were studied in the presence of ischemia and when an agent containing nicotinic acid and cysteine is administered. The above agent was found to have an antioxidative effect that was evident in the lower levels of lipid peroxides and in the normalized qualitative and quantitative content of galactosylceramides and gangliosides.

[Change in indicators of peroxide resistance in erythrocytes and lipid metabolism indicators in blood plasma during development of ischemic insult].

The authors have displayed that ischemic insults are accompanied by the significant intensification of free radical peroxidation processes both in erytrocyte membranes and in blood plasma. The changes mentioned are characterized by the simultaneous decrease of erytrocites resistance to peroxide hemolysis, as well as by the parallel lowering of alpha-tocopherol concentration in blood plasma.