Publications by authors named "L M Olde Loohuis"
Employing particles as a label is a common approach for signal amplification in various surface-based biosensors. However, the size dependency of adhesive forces can increase the likelihood of nonspecific interactions between the particles and surface. Hence, using microscale particles in surface-based sensors requires both developing surface chemistries with enhanced antifouling properties and precise methods for evaluating these properties.
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- - The PUMAS project aims to address the lack of representation of African and Latin American populations in psychiatric genetics studies by analyzing genetic data from individuals with serious mental illness (SMI), including disorders like schizophrenia and bipolar disorder, using data from 89,320 participants across four different cohorts.
- - The research involves harmonizing data from various clinical assessments to create standardized measures of mental health symptoms, which allows for more accurate genetic analyses across different diagnoses and symptoms.
- - The findings show that schizophrenia and severe bipolar disorder are the most common diagnoses among participants, and a set of 19 key symptoms has been identified, which may be useful for cross-diagnosis genetic studies.
Article Synopsis
- Accurately diagnosing bipolar disorder (BD) can take around 7 years due to its overlap with unipolar major depressive disorder (MDD), especially since the first manic episode often follows a depressive one.
- This study uses genome-wide association analyses (GWAS) and polygenic risk scores (PRS) from a large cohort to identify genetic factors that could help differentiate between BD and MDD early on.
- The results show that while BD and MDD are genetically distinct and share a continuum of genetic risk, larger future studies are needed to enhance the accuracy of these genetic predictors for early diagnosis.
Bipolar Disorder (BD) is a severe and chronic disorder characterized by recurrent episodes of depression, mania, and/or hypomania. Most BD patients initially present with depressive symptoms, resulting in a delayed diagnosis of BD and poor clinical outcomes. This study leverages electronic health record (EHR) data from the Clínica San Juan de Dios Manizales in Colombia to identify features predictive of the transition from Major Depressive Disorder (MDD) to BD.
View Article and Find Full Text PDFGenomic studies of molecular traits have provided mechanistic insights into complex disease, though these lag behind for brain-related traits due to the inaccessibility of brain tissue. We leveraged cerebrospinal fluid (CSF) to study neurobiological mechanisms , measuring 5,543 CSF metabolites, the largest panel in CSF to date, in 977 individuals of European ancestry. Individuals originated from two separate cohorts including cognitively healthy subjects (n=490) and a well-characterized memory clinic sample, the Amsterdam Dementia Cohort (ADC, n=487).
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