Publications by authors named "L M Nisimura"
Malaria represents a challenging global public health task, with being the predominant parasite in Brazil and the most widely distributed species throughout the world. Developing a vaccine against malaria demands innovative strategies, and targeting gametocyte antigens shows promise for blocking transmission prevention. Among these antigens, Pvs47, expressed in gametocytes, has shown remarkable efficacy in transmission blocking.
View Article and Find Full Text PDFNeurological commitment is a neglected manifestation of Chagas disease (CD). Meningoencephalitis mainly affects children and immunosuppressed patients, while stroke can occur with or without cardiac compromise. One of the possible causes of stroke development is microvascular commitment.
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- A study found that a positive T. cruzi PCR test in chronic Chagas disease patients is linked to poorer health outcomes.
- The research analyzed data from 333 patients, revealing a 41.1% positivity rate for the PCR test, with significant associations identified for diabetes, right bundle branch block, and past trypanocidal treatment.
- Notably, having a history of trypanocidal treatment significantly lowered the chances of a positive PCR result, highlighting its protective benefits.
Chagas disease (CD) caused by is a neglected illness and a major reason for cardiomyopathy in endemic areas. The existing therapy generally involves trypanocidal agents and therapies that control cardiac alterations. However, there is no treatment for the progressive cardiac remodeling that is characterized by inflammation, microvasculopathy and extensive fibrosis.
View Article and Find Full Text PDFBackground Chagas disease (CD) presents an ominous prognosis. The predictive value of biomarkers and new echocardiogram parameters in adjusted models have not been well studied. Methods and Results There were 361 patients with chronic CD (57.
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