Publications by authors named "L M Mikhneva"

The "middle molecules", endotoxins of peptide nature appearing in biological fluids in several diseases, cause the disorder of many regulatory processes, suppress the functions of blood cells, affect the transport characteristics of cell membranes. The review covers different aspects of formation, structure and numerous biological effects of "middle molecules", including the molecular mechanism of their biological action.

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It has been demonstrated that the plasma ratio of free and protein-bound corticosterone depends on the hypoxic degree. After two-hour hypoxia at an altitude of 10,000 m the trained and untrained animals exhibit a similar content of the free hormone (21%), with the content of total corticosterone being significantly lower in the trained rats. A study of variations in the content of free corticosterone in rats exposed to hypoxia for 20, 45 and 120 min and ACTH administration during the same time intervals has shown that the binding capacity of transcortine changes 45 min after the beginning of hypoxia.

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Empirical energy calculations were used to determine all low-energy conformations of vasoactive pentapeptide Ala-Arg-Pro-Ala-Lys, thereby three most stable conformations were distinguished. Biological testing of conformationally restricted analogs allowed to delineate the most probable "biologically active" conformation of the molecule.

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[Soluble brain proteins in autosomal trisomy syndromes].

Zh Nevropatol Psikhiatr Im S S Korsakova

February 1982

The authors examined the soluble proteins of the brain frontal lobes in the newborn with trisomias of the 13th, 18th, and 21st chromosomes (Down's, Patau's, and Edwards' syndromes). The examinations were carried out on autopsy material (the post-mortem period not exceeding 24 hours) by the method of disc electrophoresis in polyacrylamide gel. The brain tissue was taken from 17 newborn infants with Down's syndrome; 9 infants with Patau's syndrome; and 7 infants with Edwards' syndrome.

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