Organ-specific response to [Lu]DOTATATE peptide receptor radionuclide therapy (PRRT) assessed by sequential [Ga]DOTATOC PET/CT in patients with metastatic small intestine neuroendocrine tumors.

Purpose: To evaluate organ-specific response to [Lu]DOTATATE Peptide Receptor Radionuclide Therapy (PRRT) in patients with small intestine neuroendocrine tumor (SiNET) through [Ga]DOTATOC PET/CT, and to analyze tumor uptake and functional volume variations at different metastatic sites in relation to disease progression during clinical follow-up after treatment.

Methods: A retrospective analysis was conducted on 33 metastatic patients. PET/CT were performed pre-treatment (PET0), mid-treatment after two PRRT cycles (PET2), and post-treatment (PET4).

Sensitivity analysis of colored-noise-driven interacting particle systems.

We propose an efficient sensitivity analysis method for a wide class of colored-noise-driven interacting particle systems (IPSs). Our method is based on unperturbed simulations and significantly extends the Malliavin weight sampling method proposed by Szamel [Europhys. Lett.

Using AI and ML to Predict Autism Spectrum Disorder.

Autism spectrum disorder is a condition that showcases the potential usefulness of artificial intelligence (AI) and machine learning (ML). This is an area of great need, according to Dennis Wall, Ph.D.

Treatment of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis With Diffuse Alveolar Hemorrhage With Avacopan.

Objective: Avacopan, an activated complement factor 5 receptor antagonist, has been approved as adjunct therapy for severe active antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Current evidence supports the management of AAV presenting with diffuse alveolar hemorrhage (DAH) by administering glucocorticoids combined with either rituximab or cyclophosphamide in addition to supportive care. The role of avacopan in patients with DAH as a primary severe disease manifestation of AAV has not been well established.

Ultra-High to Ultra-Low: MRI Goes to Extremes.

Two of the hottest areas in magnetic resonance imaging (MRI) are at the extremes.