Publications by authors named "L M Maxfield"
Comparative Study of Two Semi-Occluded Vocal Tract Protocols: A Randomized Clinical Trial.
J Speech Lang Hear Res
November 2024
Introduction: Semi-occluded vocal tract exercises (SOVTEs) are widely used as a therapeutic tool to create flow resistance in the upper airway. The current study was a randomized controlled clinical trial to establish the efficacy of two SOVTE protocols, flow-resistant tube (FRT) and Lessac-Madsen Resonant Voice Therapy (LMRVT). Exploratory investigations included a noninferiority analysis of FRT to the widely adopted therapy protocol (LMRVT), as well as examining the dosing required to improve acoustic measures and subjective ratings.
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- Previous research indicates a connection between certain personality traits, particularly extraversion, and specific voice disorders like inflammation or nodules due to high vocal use.
- *The study aimed to analyze the relationships between self-reported vocal fatigue, demographic details, current voice perceptions, and the Big Five personality traits.
- *A sample of 73 teachers participated by completing personality assessments and vocal tasks, and multiple statistical analyses were employed to explore these relationships.*
Article Synopsis
- Successful computer simulations of vocal fold oscillation are being refined to better account for asymmetric vibrations and complex contact patterns.
- Two methods were used in the study: a high-fidelity computational model and physical model pressure measurements, focusing on normal vibration modes of the vocal folds.
- The results revealed diverse pressure distributions on vocal folds, revealing that simplified models may not accurately represent the complexity of airflow in cases with multiple contact points.
Human immunodeficiency virus type 1 (HIV-1)-specific broadly neutralizing monoclonal antibodies (bNAbs) have to date shown transient viral suppression when administered as monotherapy or as a cocktail of two antibodies. A combination of three bNAbs provides improved neutralization coverage of global viruses, which may more potently suppress viral escape and rebound. Here we performed an open-label, two-part study evaluating a single intravenous dose of HIV-1 bNAbs, PGT121, PGDM1400 and VRC07-523LS, in six adults without HIV in part 1 and a multicenter trial of up to six monthly infusions of these three bNAbs in 12 people living with HIV with an antiretroviral therapy (ART) interruption in part 2.
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- Henoch-Schönlein purpura (HSP) is a small vessel vasculitis that primarily affects children but can also occur in adults with more severe symptoms, showing differences based on geographic location.
- The study reviewed 42 studies involving 4064 adult patients from multiple regions, focusing on how HSP affects individuals differently across Asia, Europe, and the Americas.
- Findings indicated European patients had a higher occurrence of gastrointestinal and musculoskeletal issues, while American patients had less genitourinary complications, underscoring the need for standardized research to better understand these geographic variations.