Parenthood and Couples' Division of Paid Labor: The Role of Prebirth Breadwinner Couple Type in European Cross-National Perspective.

Although it is well established that parenthood affects employment decisions within households, less is known about how this effect varies across couple types in different countries. Using difference-in-differences analysis with propensity score matching and multilevel modeling with cross-level interactions, this study explores heterogeneity in the effect of parenthood on couples' division of paid labor by prebirth relative earning power in different European contexts. The results show that the decline in the female share of couples' paid working hours after parenthood is stronger in male main-earner couples than in equal-earner or female main-earner couples.

Validation of the C-X-C chemokine receptor 3 (CXCR3) as a target for PET imaging of T cell activation.

Purpose: CXCR3 is expressed on activated T cells and plays a crucial role in T-cell recruitment to the tumor microenvironment (TME) during cell-based and immune checkpoint inhibitor (ICI) immunotherapy. This study utilized a Cu-labeled NOTA-α-CXCR3 antibody to assess CXCR3 expression in the TME and validate it as a potential T cell activation biomarker in vivo.

Procedures: CXCR3 cells infiltrating MC38 tumors (B57BL/6 mice, untreated and treated with αPD-1/αCTLA-4 ICI) were quantified using fluorescence microscopy and flow cytometry.

Site-selective template-directed synthesis of antibody Fc conjugates with concomitant ligand release.

Template-directed methods are emerging as some of the most effective means to conjugate payloads at selective sites of monoclonal antibodies (mAbs). We have previously reported a method based on an engineered Fc-III reactive peptide to conjugate a radionuclide chelator to K317 of antibodies with the concomitant release of the Fc-III peptide ligand. Here, our method was redesigned to target two lysines proximal to the Fc-III binding site, K248 and K439.

Visual stimulation in the neonatal intensive care unit: A systematic literature review.

We aimed to systematically categorize evidence on the types of early visual stimulation applied to preterm infants (PTIs) admitted to neonatal intensive care units (NICUs), aiming to improve visual function parameters. This study was conducted according to PRISMA and registered in PROSPERO with CRD42022333753. Last search was conducted on March 15, 2023, in four different databases.