Publications by authors named "L M Martin-Martin"

Background: After breast cancer (BC), women may face other severe symptoms such as sleep problems. The use of simple, fast, and reliable scales is necessary in the clinic to improve patient benefits, and sleep is an important aspect to be addressed.

Objective: This study was conducted to adapt and validate the Spanish version of the satisfaction, alertness, timing, efficiency, and duration (SATED) scale for measuring sleep health in women who have completed treatment for BC in Spain (SATED-BC).

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Article Synopsis
  • The study investigates how the diversity of chimeric antigen receptor (CAR)-T cells affects clinical outcomes in treating B cell acute lymphoblastic leukemia (B-ALL).
  • Researchers analyzed clonal dynamics and gene expression using single-cell techniques in patients receiving CD19CAR-T cells, revealing notable differences in how these T cells behave during treatment.
  • Key findings include a higher CD4:CD8 ratio in successful patients' T cells at infusion and an expansion of cytotoxic T cells linked to better treatment responses across different patient cohorts.
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Rationale: Anti-CD19 chimeric antigen receptor T-cell (CAR-T) therapy is a successful treatment for B-cell malignancies associated with cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Cardiovascular toxicities have also been reported in this setting. However, there is scarce data regarding development of autonomic disorders after CAR-T cell therapy.

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Bridging therapy (BT) after leukapheresis is required in most relapsed/refractory (R/R) large B-cell lymphoma (LBCL) patients receiving chimeric antigen receptor (CAR) T cells. Bendamustine-containing regimens are a potential BT option. We aimed to assess if this agent had a negative impact on CAR-T outcomes when it was administered as BT.

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