Publications by authors named "L M Mamalyga"

Levosimendan is effective in the therapy of chronic heart failure in both mature and old rats, but the duration of its therapeutic effect differs in these age groups. In 15 days after treatment, the myocardium in old rats maintained augmented functionality, whereas in old animals, functional potencies returned to the levels observed prior to the therapy. Stimulation of tissue respiration with combined administration of L-carnitine and α-lipoic acid against the background of levosimendan treatment prolonged its therapeutic effect in mature, but not in old rats.

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Changes in the monoaminergic mechanisms in the brain at different terms after status epilepticus are determined by diverse causes and depend on the role of monoamines in the implementation of specific postictal rearrangements in CNS. Two mutually aggravating pathways cause disorders of monoaminergic mechanisms in the brain in 24 h after epileptic status: high spike-wave activity accompanied by hypocirculation that form a vicious circle; the resulting deficiency of monoamine consolidates the self-sustaining epileptic circuit. Increased activity of monoaminergic mechanisms in 5 days after epileptic status is a result of compensatory-restorative reorganization of neuronal networks and is not accompanied by spike-wave activity and hemodynamics disorders, but high convulsive readiness persists.

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Aim: To study the postictal changes in the autonomic regulation of the heart rhythm and its functional capabilities in different periods after epistatus and to assess the risk of life-threatening arrhythmias.

Material And Methods: The study was conducted on Wistar rats after epileptic status (ES). Telemonitoring of EEG and ECG was performed in the online mode using the system of the company 'ADInstruments'.

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Different levels of progressive convulsive readiness variously influence the dynamics of changes in heart rate variability parameters, inotropic and lusitropic reserves of the myocardium, which reflects the dependence of cardiac function on the level of convulsive readiness. Its increase is accompanied by a shift in autonomic balance towards potentiation of sympathetic influences on the heart, as well as a decrease in not only systolic, but also diastolic function, which reduces functional capacity of the heart and can lead to decompensation and prenosological state.

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Aim: To study circadian regulation of heart rhythm during the pre-symptomatic (PS) and early symptomatic (ESS) stages of Parkinson's disease (PD) and determine the functionally most unfavorable periods during which there is a risk of life-threatening arrhythmias.

Material And Methods: The studies were performed on C57BL/6 mice. ECG monitoring was performed in online mode using a wireless telemetry system (ADInstruments Australia).

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