Combined effect of heterogeneous target dose and heterogeneous radiosensitivity on tumor control probability for different fractionation regimens.

Purpose: To evaluate the combined effect of heterogeneous target dose and heterogeneous radiosensitivity on tumor control probability (TCP) for different number of fractions (N).

Methods: The linear-quadratic (LQ) model is employed to study dependence of TCP on N under the condition of fixed nominal biologically effective dose (BED).

Results: Formula for the optimum target dose which maximizes TCP under the condition BED=const is analytically derived.

Effect of heterogeneous target dose and radiosensitivity on BED and TCP for different treatment regimens.

To evaluate how heterogeneity of the target dose and heterogeneity of intra-tumor radiosensitivity affect biologically effective dose (BED) and tumor control probability (TCP) depending on the number of fractions (Nf).The dependences of TCP and BED in the planning target volume onNfare studied using the linear-quadratic model. In the considered case, the nominal biologically effective dose(BEDnom)is fixed and the variances of the target dose (σD) and radiosensitivity (σα) are assumed to be small.

Impact of target dose inhomogeneity on BED and EUD in lung SBRT.

Purpose: To evaluate the effect of dose heterogeneity in the treatment target on biologically effective dose (BED) for frequently used hypofractionation regimens in stereotactic body radiation therapy (SBRT).

Methods: In the case of non-uniform target dose, BED in the planning target volume (PTV) is determined by using the linear-quadratic model. An expression for BED is obtained for an arbitrary dose distribution in the PTV in the case of small variance of the target dose.

A Soft Wearable and Fully-Textile Piezoresistive Sensor for Plantar Pressure Capturing.

The trends of wearable health monitoring systems have led to growing demands for gait-capturing devices. However, comfortability and durability under repeated stress are still challenging to achieve in existing sensor-enabled footwear. Herein, a flexible textile piezoresistive sensor (TPRS) consisting of a reduced graphene oxide (rGO)-cotton) fabric electrode and an Ag fabric circuit electrode is proposed.

Effect of reoxygenation on hypofractionated radiotherapy of prostate cancer.

Purpose: To assess the role of reoxygenation of hypoxic tumor cells in hypofractionated radiotherapy of prostate cancer.

Methods: The considered radiobiological model is based on the assumption of two populations (compartments) of cells: oxygenated (aerobic) cells and hypoxic cells. After each fraction of radiation, some of the hypoxic cells reoxygenate while a fraction of initially aerobic cells becomes hypoxic.