Publications by authors named "L M Lillis"

Lipoarabinomannan (LAM) is a promising target biomarker for diagnosing subclinical and clinical tuberculosis (TB). Urine LAM (uLAM) testing using rapid diagnostic tests (RDTs) has been approved for people living with HIV (PLWH), however there is limited data regarding uLAM levels in HIV-negative (HIV-ve) adults with clinical TB. We conducted a clinical study of adults presenting with clinical TB-related symptoms at the National Lung Hospital in Hanoi, Vietnam.

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  • Salmonella enterica serovar Typhi (S. Typhi) causes Typhoid fever, and while blood cultures are the best way to diagnose it, they're hard to use in resource-limited areas.* -
  • Researchers developed a novel process control organism (PCO) as a biosafe surrogate to test various environmental surveillance methods for detecting S. Typhi in water.* -
  • The PCO successfully mimicked S. Typhi in lab tests and was consistently detected in wastewater samples from India and Malawi, making it a reliable tool for validating environmental detection methods for this pathogen.*
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  • * The new assay developed combines duplexed reverse transcriptase recombinase polymerase amplification with MS2 bacteriophage as a process control, allowing for internal verification of the testing steps.
  • * This assay provides highly sensitive detection of SARS-CoV-2 with results in under 25 minutes, visual readout options, and requires minimal equipment, making it more accessible and reducing the chances of false negatives.
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Rapid diagnostic tests (RDTs) that detect antigen indicative of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can help in making quick health care decisions and regularly monitoring groups at risk of infection. With many RDT products entering the market, it is important to rapidly evaluate their relative performance. Comparison of clinical evaluation study results is challenged by protocol design variations and study populations.

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