Publications by authors named "L M Leijser"
Diffusion MRI (dMRI) enables studying the complex architectural organization of the brain's white matter (WM) through virtual reconstruction of WM fiber tracts (tractography). Despite the anticipated clinical importance of applying tractography to study structural connectivity and tract development during the critical period of rapid infant brain maturation, detailed descriptions on how to approach tractography in young infants are limited. Over the past two decades, tractography from infant dMRI has mainly been applied in research settings and focused on diffusion tensor imaging (DTI).
View Article and Find Full Text PDFBackground: Antenatal depression is the most prevalent pregnancy-associated mental health disorder. Previous studies have identified several risk factors for antenatal depression, including partner support. However, during the COVID-19 pandemic, many relationship dynamics changed.
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- The study evaluated the use of constrained spherical deconvolution (CSD) tractography for mapping crossing fiber bundles in unsedated neonatal diffusion MRI (dMRI) and looked at how different imaging settings impact results.
- It involved analyzing dMRI data from preterm infants, comparing techniques like diffusion tensor imaging (DTI) and CSD, and assessing the effects of resolution and processing on tractography outcomes.
- Findings showed that CSD effectively reconstructed crossing fibers, while variations in imaging settings significantly influenced the properties of the reconstructed streamlines, emphasizing the need for meticulous documentation in studies.
Background: Early intervention for post-hemorrhagic ventricular dilatation (PHVD), guided by ventricular size measurements from cranial ultrasound (cUS), is associated with improved neurodevelopmental outcomes in preterm infants but benefits must be balanced against intervention risks.
Methods: Anterior horn width (AHW) and ventricular index (VI) were measured from cUS for preterm infants (<29 weeks) with intraventricular hemorrhage admitted from 2010-2018. PHVD was defined as AHW > 6 mm or VI >97th percentile for postmenstrual age.
Magnetic resonance imaging (MRI) is a non-invasive imaging technique that is commonly used for the visualization of newborn infant brains, both for clinical and research purposes. One of the main challenges with scanning newborn infants, particularly when scanning without sedation in a research setting, is movement. Infant movement can affect MR image quality and therewith reliable image assessment and advanced image analysis.
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