Publications by authors named "L M Lechuga"
Article Synopsis
- Immune checkpoint inhibitors (ICIs) are promising cancer therapies that leverage the immune system to target tumors, but they face challenges like tumor diversity and testing complexities that hinder broader use.
- To address these issues, researchers have developed a new biosensing technique using gold nanodisks to create a functional artificial membrane, allowing for quick and accurate testing of ICIs interactions with cancer cells.
- This innovative platform offers real-time analysis of immune checkpoint pathways and demonstrates high sensitivity and reliability in monitoring PD1/PD-L1 interactions, potentially enabling more efficient assessment of monoclonal antibody efficacy in cancer treatment.
The objective of this work is to: (1) demonstrate fluorine-19 (F) MRI on a 3T clinical system with a large field of view (FOV) multi-channel torso coil (2) demonstrate an example parameter selection optimization for aF agent to maximize the signal-to-noise ratio (SNR)-efficiency for spoiled gradient echo (SPGR), balanced steady-state free precession (bSSFP), and phase-cycled bSSFP (bSSFP-C), and (3) validate detection feasibility intissues.Measurements were conducted on a 3.0T Discovery MR750w MRI (GE Healthcare, USA) with an 8-channelH/F torso coil (MRI Tools, Germany).
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- α-Synuclein aggregation is a key factor in neurodegenerative disorders like Parkinson's disease (PD) and its oligomers can serve as biomarkers, but early detection methods are still lacking.
- Researchers have identified a peptide called PSMα3 that binds strongly and selectively to toxic αS oligomers, making it a promising tool for diagnosis.
- They developed a cost-effective, lab-on-a-chip biosensor that uses this peptide for real-time detection of toxic oligomers in cerebrospinal fluid, potentially improving early diagnosis of PD in clinical settings.
Article Synopsis
- The COVID-19 pandemic highlighted the risks posed by zoonotic diseases, which can jump from animals to humans, emphasizing the need for monitoring pathogens in domestic animals.
- A multi-target serological plasmonic biosensor was developed for rapid testing of SARS-CoV-2 antibodies in domestic animals, providing results in under 15 minutes with accurate sensitivity and reasonable specificity.
- This portable biosensor could serve as a reliable diagnostic tool in veterinary healthcare, expanding the use of plasmonic technology for quick and localized testing of infections in animals.
Magnetic resonance imaging (MRI) is a routine diagnostic modality in oncology that produces excellent imaging resolution and tumor contrast without the use of ionizing radiation. However, improved contrast agents are still needed to further increase detection sensitivity and avoid toxicity/allergic reactions associated with paramagnetic metal contrast agents, which may be seen in a small percentage of the human population. Fluorine-19 (F)-MRI is at the forefront of the developing MRI methodologies due to near-zero background signal, high natural abundance of 100%, and unambiguous signal specificity.
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