Publications by authors named "L M Kamminga"
Article Synopsis
- Recent studies suggest that environmental chemicals may increase the risk of metabolic diseases by altering epigenetic mechanisms, affecting lipid metabolism and gene expression, particularly through the role of the Ezh2 enzyme.
- The research utilized zebrafish embryos to evaluate how exposure to the Ezh1/2 inhibitor PF-06726304 and the chemical tributyltin (TBT) impacted lipid accumulation and chromatin status, revealing significant changes in epigenetic markers related to metabolic pathways.
- Findings indicated that exposure to these chemicals led to increased lipid accumulation and differential gene expression, with specific alterations in chromatin accessibility influencing lipid metabolism and adipogenesis during zebrafish development.
Polycomb group (PcG) proteins are transcriptional repressors that are important regulators of cell fate during embryonic development. Among them, Ezh2 is responsible for catalyzing the epigenetic repressive mark H3K27me3 and is essential for animal development. The ability of zebrafish embryos lacking both maternal and zygotic to form a normal body plan provides a unique model for comprehensively studying Ezh2 function during early development in vertebrates.
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- The Polycomb group (PcG) protein family, particularly Rnf2, was studied in zebrafish to understand its impact on gene regulation related to heart development.
- Researchers found that without Rnf2, genes normally kept in check became overactive, especially genes that should be regulated by Rnf2.
- In rnf2 mutant hearts, there was a notable increase in heart transcription factors and a decrease in genes specific to heart chambers, suggesting that the lack of Rnf2 disrupts normal heart development and function.
Polycomb group (PcG) proteins are essential regulators of epigenetic gene silencing and development. The PcG protein enhancer of zeste homolog 2 (Ezh2) is a key component of the Polycomb Repressive Complex 2 and is responsible for placing the histone H3 lysine 27 trimethylation (H3K27me3) repressive mark on the genome through its methyltransferase domain. Ezh2 is highly conserved in vertebrates.
View Article and Find Full Text PDFPolycomb Group (PcG) genes are transcriptional repressors that are described to be important during development and differentiation. There is significant interest in PcGs proteins because of their role in stem cell biology and tumorigenesis. In this study we characterize the expression of a selection of PcG genes in the adult germline of zebrafish and during embryogenesis.
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