Publications by authors named "L M Jongen"
Purpose: In breast conserving surgery, accurate lesion localization is essential for obtaining adequate surgical margins. Preoperative wire localization (WL) and radioactive seed localization (RSL) are widely accepted methods to guide surgical excision of nonpalpable breast lesions but are limited by logistical challenges, migration issues, and legislative complexities. Radiofrequency identification (RFID) technology may offer a viable alternative.
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- Multiple studies have indicated that high contralateral parenchymal enhancement (CPE) in breast MRI may improve long-term survival rates for patients with ER-positive, HER2-negative breast cancer, but more research is needed due to inconsistent findings.
- This study aimed to validate the connection between CPE and long-term survival using a large group of women with specific breast cancer characteristics, examining overall survival (OS), recurrence-free survival (RFS), and distant RFS (DRFS).
- Results showed that higher CPE was linked to better OS rates after 10 years, but it didn't significantly impact RFS or DRFS; additionally, the effect of endocrine therapy in relation to CPE couldn't be determined accurately.
Article Synopsis
- Breast cancer screening has improved, allowing doctors to find early-stage cancers that can't be felt, which means better chances for treatment.
- The study is testing a new way to help doctors find these hidden cancers during surgery using RFID technology, which is safer and doesn't use radiation.
- Researchers want to see if this new method reduces the need for extra surgeries and how easy it is for doctors to use, while also making sure the patients have a good experience.
Multigene signatures (MGS) are used to guide adjuvant chemotherapy (aCT) decisions in patients diagnosed with estrogen receptor (ER)-positive HER2-negative early breast cancer. We used results from three MGS (Oncotype DX® (ODX), MammaPrint® (MP) or Prosigna®) and assessed the concordance between high or low risk of recurrence and the predicted risk of recurrence based on statistical models. In addition, we looked at the impact of MGS results on final aCT administration during the multidisciplinary meeting (MDM).
View Article and Find Full Text PDFBackground: High levels of stromal tumor-infiltrating lymphocytes (sTIL) are associated with increased pathological complete response (pCR) rate and longer survival after neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) patients. Here, we evaluated the value of sTIL in predicting pCR and explored prognosis in TNBC patients treated with neoadjuvant chemotherapy according to body mass index (BMI).
Methods: sTIL were scored centrally on pretreatment biopsies from 2 retrospective series of nonunderweight TNBC patients (n = 445).