Transient chemotherapy-induced alopecia after successful reversal of 5-fluorouracil myelosuppression and neurotoxicosis in a 9-month-old dog.

Background: 5-Fluorouracil (5-FU) cream is a common human topical chemotherapy agent with potentially fatal neurotoxic effects on dogs if accidentally ingested. There are seldom reports in veterinary literature describing the successful outcome of intervention after accidental ingestion of 5-FU cream.

Case Summary: A 9-month-old spayed female labradoodle presented 14 h after ingesting an unknown amount of 40 g tube of Efudex cream (5% 5-FU).

CHANGES IN ANTIOXIDANT CAPACITY OF KOALAS () BASED ON HEALTH STATUS AND MEASUREMENT OF THE ANTIOXIDANT ASCORBATE IN EUCALYPT LEAVES.

Antioxidants have a crucial role in protecting the body from oxidative stress, which would otherwise result in cellular damage and possibly predispose animals to disease. The antioxidant capacity of koalas () and its association with health or disease status is currently unknown. Ascorbate, a dietary antioxidant, has previously been identified in a few eucalypt species eaten by koalas.

Analgesia and serum concentrations of extradural, subdural and intraperitoneal fentanyl in a rat model.

The effects of epidural, subdural and intraperitoneal fentanyl were determined on the tail flick response of the rat using the response latency as a measure of analgesia. Dose-time-response curves were generated for incremental doses of fentanyl administered at constant injection volumes. Serum concentrations at varying doses were determined using a radioimmunoassay technique.