Comparative Impact of Alternate-Day Fasting and Time-Restricted Feeding on Placental Function and Fetal Development in Maternal Obesity.

Background: Maternal obesity detrimentally affects placental function and fetal development. Both alternate-day fasting (ADF) and time-restricted feeding (TRF) are dietary interventions that can improve metabolic health, yet their comparative effects on placental function and fetal development remain unexplored.

Objectives: This study aims to investigate the effects of ADF and TRF on placental function and fetal development during maternal consumption of a high-fat diet (HFD).

Flow Behavior Analysis of the Cold Rolling Deformation of an M50 Bearing Ring Based on the Multiscale Finite Element Model.

Through the ferrite single-phase parameters of M50 bearing steel obtained based on nanoindentation experiments and the representative volume element (RVE) model established based on the real microstructure of M50, this paper established a multiscale finite element model for the cold ring rolling of M50 and verified its accuracy. The macroscale and mesoscale flow behaviors of the ring during the cold rolling deformation process were examined and explained. The macroscopic flow behavior demonstrated that the stress distribution was uniform following rolling.

Individualized brain radiomics-based network tracks distinct subtypes and abnormal patterns in prodromal Parkinson's disease.

Individuals in the prodromal phase of Parkinson's disease (PD) exhibit significant heterogeneity and can be divided into distinct subtypes based on clinical symptoms, pathological mechanisms, and brain network patterns. However, little has been done regarding the valid subtyping of prodromal PD, which hinders the early diagnosis of PD. Therefore, we aimed to identify the subtypes of prodromal PD using the brain radiomics-based network and examine the unique patterns linked to the clinical presentations of each subtype.

Peripheral blood immune cell dynamics associate with growth of incidental indeterminate pulmonary nodules.

Objectives: Previous studies suggest peripheral blood immune cells associate with the progression and prognosis of lung cancer. The main purpose of this study was to explore the association of peripheral immune cell and its dynamics with the growth of pulmonary nodules.

Materials And Method: Of 9280 subjects whom had blood cell counts and chest CT scan in health check-up, 1068 participants were enrolled with the incidental pulmonary nodules of above 5 mm in diameter and subsequently followed up for 2 years.