Publications by authors named "L M Hales"
Article Synopsis
- - The study investigates why women, particularly mothers and wives, tend to be more prevalent as living kidney donors, highlighting the need to consider relational, community, and socio-cultural factors in decision-making rather than just individual motivations.
- - A systematic review of 16 studies from 13 countries revealed minimal differences in individual motives between male and female donors, but significant variations were found in relational, community, and socio-cultural influences, such as family dynamics and societal norms.
- - The findings indicate that gender disparities in living kidney donation stem from complex interconnections among various factors, suggesting the necessity of addressing systemic contributors to gender inequities to promote more balanced donation practices.
Poor sleep is becoming increasingly prevalent and is associated with adverse health outcomes. Sunlight exposure may improve sleep by regulating circadian rhythms, increasing vitamin D, and influencing melatonin production. However, research on the sunlight-sleep association is limited, especially outside of cross-sectional designs.
View Article and Find Full Text PDFBackground And Aims: Familial hypercholesterolaemia (FH) is a highly prevalent monogenic disorder characterized by elevated LDL cholesterol (LDL-C) levels and premature atherosclerotic cardiovascular disease. Sex disparities in diagnosis, lipid-lowering therapy, and achieved lipid levels have emerged worldwide, resulting in barriers to care in FH. A systematic review was performed to investigate sex-related disparities in treatment, response, and lipid target achievement in FH (PROSPERO, CRD42022353297).
View Article and Find Full Text PDFLiving kidney donors (LKDs) undertake a complex and multifaceted journey when pursuing donation and have several unmet healthcare needs. A comprehensive understanding of these needs across their entire donation trajectory can help develop a patient-centered care model. We conducted a scoping review to synthesize empirical evidence, published since 2000, on LKDs' experiences with healthcare from when they decided to pursue donation to postdonation care, and what they reported as their care needs.
View Article and Find Full Text PDFHypoparathyroidism, a deficiency of parathyroid hormone (PTH), results in hypocalcemia, hyperphosphatemia, and hypercalciuria. The disease is poorly controlled by calcium and vitamin D supplements or native PTH(1-84) replacement therapy. A version of PTH is being developed using D-VITylation technology, whereby vitamin D is conjugated to a therapeutic peptide, which confers a long plasma half-life by virtue of binding to the abundant vitamin D binding protein (DBP).
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