Publications by authors named "L M Giangregorio"

Objectives: To describe lumbar spine (LS) trabecular bone score (TBS) values after SCI, and to explore the differences in fractures risk assessment between FRAX® and TBS-adjusted FRAX® in individuals living with chronic SCI.

Methods: Baseline dual-energy x-ray absorptiometry (DXA) scans from an established cohort were acquired using a Hologic Discovery QDR 4500. TBS measurements were performed using the TBS iNsight software version 2.

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Background: Essential amino acid (EAA) and omega-3 fatty acid ingestion independently attenuate leg skeletal muscle disuse atrophy in uninjured persons. However, no data exist regarding the effectiveness of combined EAA and omega-3 fatty acid ingestion to mitigate skeletal muscle disuse atrophy in response to anterior cruciate ligament reconstruction (ACLR) surgery. This pilot trial will explore the feasibility of recruitment and retention of ACLR outpatients from a single center across 18 months to consume either a combination of omega-3 fatty acids and EAAs, or a placebo control, for 4 weeks before and 2 weeks after surgery.

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Unlabelled: People with prior lean mass loss had a ~ 10% higher risk of MOF and ~ 22-26% higher risk of hip fracture, and the results were similar in people on anti-osteoporosis medications. Loss of lean mass is associated with increased fracture risk. Patients should be encouraged to pursue strategies to prevent loss of lean mass.

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Article Synopsis
  • Individuals with spinal cord injury (SCI) commonly experience significant bone loss, but lumbar spine bone mineral density (BMD) can appear normal or even high, prompting concerns about measurement errors.
  • A study analyzed DXA scans from 58 participants with chronic SCI to identify potential errors affecting lumbar spine BMD measurements at baseline and after 2 years.
  • Findings showed that 93% of scans had at least one error source, with common issues including facet sclerosis and difficulties in accurately detecting bone edges, suggesting the need to reconsider the use of lumbar spine BMD for assessing fracture risk in SCI patients.
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Physical activity improves the well-being of persons living with dementia but few exercise programs include them. The Dementia-Inclusive Choices for Exercise (DICE) toolkit aims to improve exercise providers' understanding of dementia and ability to support persons living with dementia in physical activity. We evaluated the co-designed DICE toolkit with exercise providers using a mixed-methods approach comprising pre/post questionnaires and interviews and reflection diaries.

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