Publications by authors named "L M Gerace"
Non-coding RNAs and neuroinflammation: implications for neurological disorders.
Exp Biol Med (Maywood)
March 2024
Neuroinflammation is considered a balanced inflammatory response important in the intrinsic repair process after injury or infection. Under chronic states of disease, injury, or infection, persistent neuroinflammation results in a heightened presence of cytokines, chemokines, and reactive oxygen species that result in tissue damage. In the CNS, the surrounding microglia normally contain macrophages and other innate immune cells that perform active immune surveillance.
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- The study aimed to predict the prevalence of comorbidities and multimorbidity among people living with HIV in the US by 2030, utilizing the PEARL agent-based simulation model.
- It forecasted that the population of individuals on antiretroviral therapy (ART) will grow from 670,000 in 2020 to 908,000 by 2030, reflecting increases among various demographic groups, including Hispanic and Black/African American individuals.
- Key findings indicated a rise in mental health issues like depression and anxiety, projecting an increase from 60% to 64% prevalence, while hypertension was expected to decrease.
Agreement of activity monitors for assessment of patients with sub-acute stroke in an inpatient rehabilitation facility.
Disabil Rehabil Assist Technol
August 2024
Purpose: Determine the level of agreement of three activity monitors compared with the gold standard (video review) on the activity level of patients with stroke.
Methods: A prospective, observational, agreement study was performed on 47 individuals with sub-acute stroke in an inpatient rehabilitation facility. Data was collected during one physical therapy session.
Article Synopsis
- The study explores the impact of different mortality rate models on forecasts of HIV population size and deaths, emphasizing the importance of considering subgroup-specific characteristics in the analysis.* -
- Using an agent-based simulation, the researchers assessed various scenarios, including all PWH and specific subgroups by sex, race/ethnicity, and HIV acquisition risk, to understand how these factors affect mortality predictions.* -
- Findings indicate that models ignoring subgroup-specific mortality rates and allowing unlimited reductions in mortality may lead to significant underestimations of future deaths among people with HIV.*
The nuclear envelope (NE) is a subdomain of the ER with prominent roles in nuclear organization, which are largely mediated by its distinctive protein composition. We developed methods to reveal low-abundance transmembrane (TM) proteins concentrated at the NE relative to the peripheral ER. Using label-free proteomics that compared isolated NEs with cytoplasmic membranes, we first identified proteins with apparent NE enrichment.
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