X-Linked Hypophosphatemia Management in Children: An International Working Group Clinical Practice Guideline.

Background: An International Working Group (IWG) developed new guidelines on the diagnosis, evaluation, management, and monitoring of X-linked hypophosphatemia (XLH) in children. Over the past 5 years, important advances have occurred in our understanding of the presentation, complications and treatment of XLH.

Methods: A group of 50 international experts in XLH from Canada, the United States, Europe, Asia and South America, along with methodology experts and patient partners, held 18 teleconference meetings in 2023-2024.

Navigating Endodontic Care: Perspectives Among Dentists Managing Older Adults-A Qualitative Study.

Using a qualitative approach, this study explored the perspectives and practices among New Zealand general dental practitioners (GDPs) providing endodontic care to older adults. Semi-structured questions guided focus group discussions with 18 GDPs who had varied practice experience and characteristics. Transcribed data were analysed and using reflexivity, six primary themes emerged to provide context: philosophies towards managing older adults; confidence; pulpal diagnosis; treatment planning; informed consent; and referral to an endodontist.

Effect of diabetes and hyperglycaemia on the physical and mechanical properties of dentine: a systematic review.

Objectives: The aim of this systematic review was to assess the effect of DM (Type 1 and Type 2 Diabetes) and hyperglycaemia on the physical and mechanical properties of dentine which is critical for successful endodontic treatment.

Method: An electronic search of the following databases: PubMed, MEDLINE, Web of Science and the grey literature was performed up until July 2024. In vitro and in vivo studies on the effect of DM or hyperglycaemia on the mechanical and physical properties of dentine were included.

Angiogenic effects of Type 2 diabetes on the dental pulp.

Aim: To investigate the influence of type 2 diabetes (T2D) and hyperglycaemia on blood vessels and angiogenic markers in the dental pulp.

Methodology: Extracted non-carious permanent molar teeth were collected from patients with well-controlled T2D (n = 10) and non-T2D (controls) (n = 10). The pulp was examined qualitatively using haematoxylin and eosin and Van Gieson stains.

Long-Range Proton Channels Constructed via Hierarchical Peptide Self-Assembly.

The quest to understand and mimic proton translocation mechanisms in natural channels has driven the development of peptide-based artificial channels facilitating efficient proton transport across nanometric membranes. It is demonstrated here that hierarchical peptide self-assembly can form micrometers-long proton nanochannels. The fourfold symmetrical peptide design leverages intermolecular aromatic interactions to align self-assembled cyclic peptide nanotubes, creating hydrophilic nanochannels between them.