Publications by authors named "L M Freeman"
Background: Parasitic nematodes significantly undermine global human and animal health and productivity. Parasite control is reliant on anthelmintic administration however over-use of a limited number of drugs has resulted in escalating parasitic nematode resistance, threatening the sustainability of parasite control and underscoring an urgent need for the development of novel therapeutics. FMRFamide-like peptides (FLPs), the largest family of nematode neuropeptides, modulate nematode behaviours including those important for parasite survival, highlighting FLP receptors (FLP-GPCRs) as appealing putative novel anthelmintic targets.
View Article and Find Full Text PDFBackground/objectives: Obesity is a major public health concern that increases the risk of chronic diseases. In obesity, adipose tissue undergoes remodeling, which is associated with chronic low-grade inflammation and disruption of its homeostatic mechanisms including endoplasmic reticulum (ER) function and autophagy. Fish oil (FO) and tart cherry (TC) have known anti-inflammatory properties.
View Article and Find Full Text PDFThe concept of severity in healthcare is multidimensional and subjective. It is a primary consideration in reproductive genetic carrier screening design where the focus is providing reproductive couples with information about the chance of severe genetic conditions in their offspring. When offering this screening, it is important to understand how condition severity is perceived and incorporated into reproductive decision-making.
View Article and Find Full Text PDFArticle Synopsis
- A study examined the link between pesticide use and the risk of rheumatoid arthritis (RA) among licensed pesticide applicators, primarily white male farmers in North Carolina and Iowa, observing data from 1993 to 2016.
- Out of over 22,000 applicators aged 67 and older, 161 developed RA after not having claims for at least a year, with nine specific pesticides showing increased risk.
- Notable pesticides associated with elevated RA risk include malathion, carbaryl, and various herbicides and fungicides, indicating a potential health concern for older adults exposed to these chemicals.
Incorporation of the central vein sign into the McDonald criteria.
Mult Scler Relat Disord
November 2024
Background: Diagnosis of multiple sclerosis (MS) frequently relies on MRI dissemination in time (DIT) and space (DIS), as codified in 2017 McDonald criteria (McD 2017). The central vein sign (CVS) is a proposed MS diagnostic biomarker, but its optimal incorporation into McD 2017 has not been extensively studied.
Objective: Evaluate the diagnostic performance of several methods incorporating CVS into McD 2017 radiological DIS criteria.