Maternal high-fat diet and obesity impact palatable food intake and dopamine signaling in nonhuman primate offspring.

Objective: To utilize a nonhuman primate model to examine the impact of maternal high-fat diet (HFD) consumption and pre-pregnancy obesity on offspring intake of palatable food and to examine whether maternal HFD consumption impaired development of the dopamine system, critical for the regulation of hedonic feeding.

Methods: The impact of exposure to maternal HFD and obesity on offspring consumption of diets of varying composition was assessed after weaning. The influence of maternal HFD consumption on the development of the prefrontal cortex-dopaminergic system at 13 months of age was also examined.

Healthcare worker knowledge and attitudes regarding influenza immunization and childhood vaccination.

We surveyed healthcare workers (HCWs) about influenza vaccination and routine childhood vaccinations. We found that most HCWs' children received vaccinations, despite concerns regarding safety and efficacy. HCWs who received influenza vaccine were more likely to immunize their children against influenza, although a substantial proportion of HCWs' children did not receive influenza vaccination.

Health care worker knowledge, attitudes, and beliefs regarding mandatory influenza vaccination.

Objective: To determine the attitudes, beliefs, and knowledge of children's hospital health care workers toward mandatory influenza vaccination.

Design: Self-administered, Web-based questionnaire.

Setting: A large, tertiary children's hospital.

Adoptive immunotherapy with tumor-infiltrating lymphocytes and interleukin-2 in patients with metastatic malignant melanoma and renal cell carcinoma: a pilot study.

Purpose: The objective of this study was to determine the tolerance and effect of moderate-dose recombinant human interleukin-2 (rHu IL-2) and tumor-infiltrating lymphocytes (TIL) in patients with metastatic melanoma (MM) or renal cell carcinoma (RCC) refractory to standard therapy.

Patients And Methods: Twenty-six patients (18 MM and eight RCC) were entered onto this pilot study. TIL were isolated from fresh biopsy material and activated with anti-CD3 antibody, OKT3, for 48 hours and expanded in 100 IU/mL r-methionyl Hu IL-2 alanine 125 (r-met Hu IL-2 [ala-125]).