Publications by authors named "L M Deshpande"
This study addresses the use of other echinocandins as surrogate markers to predict the susceptibility of rezafungin against the six most common spp. The Clinical Laboratory Standards Institute (CLSI) reference broth microdilution method was performed to test 5,720 clinical isolates of six different species. Species-specific interpretative criteria by CLSI breakpoints or epidemiological cutoff values were applied.
View Article and Find Full Text PDFNeutrophil elastase activates macrophage calpain as a mechanism for phagocytic failure.
Am J Physiol Lung Cell Mol Physiol
January 2025
Neutrophil elastase (NE), elevated in the cystic fibrosis (CF) airway, causes macrophage phagocytic failure. We previously reported that NE increases the release of protease calcium ion-dependent papain-like cysteine protease-2 (Calpain-2) in macrophages. We hypothesized that NE mediates macrophage failure through activation of Calpains.
View Article and Find Full Text PDFArticle Synopsis
- * A significant 82.1% of the isolates showed resistance to fluconazole, while 17.9% were resistant to amphotericin B; however, rezafungin remained effective against 96.2% of the isolates.
- * The majority of isolates belonged to South Asian Clade I, with high fluconazole resistance, alongside notable mutations detected in resistance-related genes, highlighting
isolates from the United States (n = 1038; 2019-2021) were susceptible to omadacycline (99.8%), levofloxacin (99.7%), and ceftriaxone (98.
View Article and Find Full Text PDFArticle Synopsis
- Pneumococcal conjugate vaccines (PCVs), especially newer versions like PCV20, have a significant potential to reduce ear infections (otitis media) in young children by covering more serotypes of bacteria.
- A study examined 199 isolates from the middle ear fluid of U.S. children, finding that 56.8% were from kids under age 2 and identifying key serotypes that contribute to infections, with PCV20 covering 54.8% of these.
- The research indicated a concerning level of antimicrobial resistance, with 45.2% of isolates being non-susceptible to penicillin, suggesting that expanding the coverage of vaccines could help combat both susceptible and resistant types of pneumoc