Publications by authors named "L M Dembry"
Clinical outcomes following dalbavancin administration in patients with barriers to outpatient parenteral antimicrobial therapy.
Antimicrob Steward Healthc Epidemiol
May 2022
Between 2016 and 2021, we retrospectively identified 42 patients receiving ≥1 dose of dalbavancin for osteomyelitis, skin and soft-tissue infection, endocarditis or bacteremia, or septic arthritis. Median antibiotic duration prior to dalbavancin administration was 7 days. Within 90 days, 93% achieved clinical cure, 12% were readmitted, 12% developed hepatotoxicity, and 5% died.
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- Surgical site infections (SSI) are a major concern for liver transplant patients, particularly in children, and this study aimed to understand their incidence, causes, and effects in a pediatric population.
- Out of 86 patients studied, 9.3% developed SSIs, with a higher incidence in those receiving segmental grafts compared to whole grafts, and SSIs were linked to higher rates of biliary complications and reoperations.
- Despite the presence of SSIs, there was no significant difference in long-term graft or patient survival, suggesting that while SSIs are a concern, their impact on mortality is minimal and should not deter the use of segmental grafts in liver transplants.
Article Synopsis
- We conducted a survey to evaluate the urine culture practices of trainees and the effects of an educational intervention provided both online and in-person.
- After the intervention, trainee scores improved in all areas assessed in the post-survey, indicating better understanding and practices.
- However, the mode of education (whether online or in-person) did not significantly affect the outcome, as scores were similar regardless of how the material was delivered (P=0.91).
We evaluated adverse drug events (ADEs) by chart review in a random national sample of 428 veterans with coronavirus disease 2019 (COVID-19) who received tocilizumab (n = 173 of 428). ADEs (median time, 5 days) occurred in 51 of 173 (29%) and included hepatoxicity (n = 29) and infection (n = 13). Concomitant medication discontinuation occurred in 22% of ADE patients; mortality was 39%.
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