Publications by authors named "L M De Wouters"
Article Synopsis
- Hypocretin deficiency leads to type 1 narcolepsy, which is associated with excessive daytime sleepiness and a high prevalence of overweight and obesity in patients.
- A study compared energy expenditure in ten males with narcolepsy to nine healthy controls using respiration chamber calorimetry and doubly labelled water.
- Results showed no significant differences in energy expenditure or physical activity between the two groups, suggesting that weight gain in narcolepsy might be influenced by factors other than metabolism, such as dietary habits.
Background: The evaluation of myocardial ischemia in patients with aortic valve stenosis (AS) with concomitant coronary artery disease (CAD) and possible microvascular dysfunction (MVD) is challenging because fractional flow reserve (FFR) and the resting full-cycle ratio (RFR) have not been validated in this clinical setting.
Objectives: The objectives of this study in patients with AS and CAD were: 1) to describe the relationship between hyperemic and resting indexes; 2) to investigate the acute and long-term effects of aortic valve replacement (AVR) on epicardial indexes and microvascular function; 3) to assess the impact of these changes on clinical decision making; and 4) to determine FFR/RFR ischemia cutoff points in AS.
Methods: In this prospective multicentric study, we performed serial measurements of FFR and RFR and evaluated MVD by means of coronary flow reserve, the index of microvascular resistance, and microvascular resistance reserve in patients with severe AS and intermediate to severe CAD before and 6 months after AVR.
Hydrogeological numerical models are essential for assessing radioactive waste disposal by understanding groundwater flow systems. These models typically rely on hydraulic head data, with other state variables often underutilized in model inversions. In Flanders' Neogene aquifer, where safety studies for Boom Clay are ongoing, existing models face uncertainties due to dependence on hydraulic heads alone.
View Article and Find Full Text PDFBackground: Myocardial diastolic function assessment in children by conventional echocardiography is challenging. High-frame rate echocardiography facilitates the assessment of myocardial stiffness, a key factor in diastolic function, by measuring the propagation velocities of myocardial shear waves (SWs). However, normal values of natural SWs in children are currently lacking.
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