Transcriptomic analysis reveals a critical role for activating Gα mutations in spontaneous feline hyperthyroidism.

Feline hyperthyroidism (FHT) is a debilitating disease affecting > 10% of elderly cats. It is generally characterised by chronic elevation of thyroid hormone in the absence of circulating TSH. Understanding of the molecular pathogenesis of FHT is currently limited.

Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes.

Diabetes mellitus involves both insufficient insulin secretion and dysregulation of glucagon secretion. In healthy people, a fall in plasma glucose stimulates glucagon release and thereby increases counter-regulatory hepatic glucose production. This response is absent in many patients with type-1 diabetes (T1D), which predisposes to severe hypoglycaemia that may be fatal and accounts for up to 10% of the mortality in patients with T1D.

Ultrasound technology as a tool to teach basic concepts of physiology and anatomy in undergraduate and graduate courses: a systematic review.

Many publications describe use of ultrasound imaging in teaching of clinical courses, primarily integrated with clinical applications. More recently there have been increasing numbers of papers describing ultrasound as a tool primarily for teaching basic anatomy and physiology concepts rather than clinical applications. Of these, many have described qualitative analysis with a consensus that its use is viewed very positively by students for aiding learning.