Publications by authors named "L M Dar"
Background: Inflammatory bowel disease (IBD) presents unique challenges in elderly patients due to comorbidities and treatment-related risks.
Objectives: This study evaluates ustekinumab (UST) and vedolizumab (VDZ) efficacy and safety in elderly Crohn's disease (CD) patients.
Design: A retrospective cohort study at a tertiary medical center.
Article Synopsis
- The study aimed to evaluate the effectiveness of combining endometrial aspiration and sonohysterography for screening endometrial cancer and hyperplasia in women over 50.
- Conducted from February 2014 to October 2020, the study involved 1,170 women, revealing significant findings: 7% were diagnosed with cancer, and 3.6% with hyperplasia, with most cancers detected within a year.
- The combined screening method showed high sensitivity (99.1%) but lower specificity (24.9%), while a sequential approach improved specificity and positive predictive value, indicating that the combined method is a promising tool for detecting endometrial issues.
Burn injuries are serious injuries that have a big impact on a person's health and can even cause death. Incurring severe burns can incite an immune response and inflammation within the body, alongside metabolic changes. It is of utmost importance to grasp the fact that the effects of the burn injury extend beyond the body, affecting the mind and overall well-being.
View Article and Find Full Text PDFSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered an ongoing global pandemic, necessitating rapid and accurate diagnostic tools to monitor emerging variants and preparedness for the next outbreak. This study introduces a multidisciplinary approach combining Fourier Transform Infrared (FTIR) microspectroscopy and Machine learning to comprehensively characterize and strain-type SARS-CoV-2 variants. FTIR analysis of pharyngeal swabs from different pandemic waves revealed distinct vibrational profiles, particularly in nucleic acid and protein vibrations.
View Article and Find Full Text PDFIntroduction: Nasopharyngeal carcinoma (NPC), arising from nasopharyngeal epithelium is caused by Epstein-Barr virus (EBV). It is common in South China, South East Asia and North East India. The aim and objectives of this study were to determine the prevalence of EBV in formalin-fixed paraffin-embedded (FFPE) tissue sections of clinically suspected NPC patients, correlate the results of polymerase chain reaction (PCR) with histopathology findings, and to determine the utility of tissue EBV DNA as a diagnostic bio-marker.
View Article and Find Full Text PDF