The 3rd Educational Course of the European Burns Association (EBA).

Abstracts of the plenary sessions, workshops, and poster presentations of the 3rd EBA Educational Course in Porto, Portugal, 17-18 October 2024.

Genetic variant in the AGT gene (rs699-GG) is associated with severe COVID-19 in Brazilian patients.

The COVID-19 pandemic has been the largest pandemic of the past century, and various genetic factors have played a significant role in this context. This study aimed to analyze the frequency and association between specific SNPs rs3806268 (NLRP3), rs4925543 (NLRP3), rs12150220 (NLRP1), rs455060 (NLRC4), rs699 (AGT), rs1137101 (LEPR), and rs1801133 (MTHFR) and severe/critical outcomes in Brazilian patients with COVID-19. A total of 100 patients were included in the study, comprising 66 cases and 34 controls.

Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies.

Inhibition of cholinesterases, combined with antioxidant activity, metal-chelating capacity, and neuroprotection, is recognized as an effective multitarget therapy for the treatment of Alzheimer's disease (AD). Based on our in-house thiosemicarbazone-acridine compounds, this study recognized these derivatives as possible multi-target-directed ligand (MTDL). Initial screening against cholinesterases identified CL-01, which exhibited a promising IC value of 0.

Accelerometer-Measured Volumes of Moderate-to-Vigorous Physical Activity and Functional Fitness in Older Adults.

The objective of this study is to investigate the association between different volumes of accelerometer-measured moderate-to-vigorous physical activity (MVPA) and functional fitness in older adults in a cross-sectional study (n = 242; 66 ± 5 years; 80% women). MVPA was assessed by accelerometer for 1 week. Based on the MVPA recommendations, the participants were classified as: (a) inactive (<50 min/week), (b) somewhat active (50-99 min/week), (c) moderately active (100-149 min/week), and (d) active (≥150 min/week).

Bacterial dynamics and volatile metabolome changes of vacuum-packaged beef with different pH during chilled storage.

This study aimed to assess the growth of spoilage bacteria in Brazilian vacuum-packed beef across different pH ranges (5.4-5.8, 5.