Publications by authors named "L M Boland"
Article Synopsis
- The study examines the differences between families who consented to postmortem tissue donation and those who declined it in pediatric CNS malignancy cases at a single institution.
- Out of 23 patient families, only 35% consented to participate, revealing racial and socioeconomic disparities, including a higher percentage of White, non-Hispanic/Latino consenters and a greater prevalence of private insurance among them.
- The researchers suggest that improving communication, particularly with non-English-speaking families, is vital to address these disparities and enhance participation in future CNS research.
The cut-open oocyte Vaseline gap technique is a powerful electrophysiological method for the characterization of ion channels. However, traditional amplifiers for cut-open oocyte Vaseline gap are labor intensive and require significant user expertise. We introduce an innovative, open-source digital amplifier system with high-speed digitization and software-controlled electronics for computer-driven automation.
View Article and Find Full Text PDFGlioblastoma is a Grade 4 primary brain tumor defined by therapy resistance, diffuse infiltration, and near-uniform lethality. The underlying mechanisms are unknown, and no treatment has been curative. Using a recently developed creatine kinase inhibitor (CKi), we explored the role of this inhibitor on GBM biology in vitro.
View Article and Find Full Text PDFArticle Synopsis
- Frailty in elderly patients is linked to higher rates of morbidity and mortality post-surgery, and its relationship with decisional regret (the feeling of regret about undergoing surgery) is not well understood.
- A study of 669 patients aged 65 and older undergoing elective noncardiac surgery found that 43.8% lived with frailty, and while frailty was initially related to increased decisional regret one year after surgery, this association weakened after adjusting for other factors like age, sex, and mental health.
- The results indicated that the type of surgery may influence the relationship between frailty and decisional regret, suggesting that more research is needed to fully understand these connections.