Gemcitabine and vinorelbine in advanced nonsmall cell lung carcinoma: a phase II study.

Background: The authors conducted a Phase II study to evaluate the activity of the combination of gemcitabine and vinorelbine in patients with advanced nonsmall cell lung carcinoma (NSCLC).

Methods: Patients were eligible if they had Stage IIIB (malignant pleural effusion) or Stage IV NSCLC, no prior chemotherapy, and Cancer and Leukemia Group B performance status (PS) 0-2. Patients with brain metastases were eligible if they were neurologically stable after brain irradiation.

[The biopsychosocial profile of juvenile delinquents referred to a mental health clinic].

This study consists of a record review of the juvenile delinquents admitted to a state child and adolescent mental health clinic in Puerto Rico during 1987. The review was done using as reference models the basic findings of other researchers in Puerto Rico and the United States and mainly of those of Dorothy Lewis. The purpose of the study was to describe the bio-psychosocial profile of the juvenile delinquents admitted to this clinic.

Phase II trial of recombinant beta (IFN-betaser) interferon in the treatment of metastatic breast cancer.

Nine patients with metastatic breast cancer received 30 x 10(6) I.U. of Interferon - Betaser (Betaseron) intravenously daily times five for two consecutive weeks followed by a two week rest period.

Respiratory tract fistulae in recurrent aerodigestive cancers after chemotherapy.

Bronchoesophageal fistulae, a form of respiratory tract fistula, occurred in four patients with squamous cell carcinoma arising in the esophagus or left bronchus after cytoreductive chemotherapy. All four had locoregional cancer, recurrent after high-dose external radiation therapy. Esophageal cancer was treated with sequential intravenous cisplatin 100 mg/m2 (day 1) and 5-fluorouracil (5-FU) 40 mg/m2/hour X 120 (days 2-7).

Sickling dynamics of red blood cells and other physiologic studies during anesthesia.

Nineteen patients with electrophoretically proven sickle cell diseases were studied prospectively at intervals, using halothane, methoxyflurane, cyclopropane, and fluroxene. Simultaneous venous and arterial samples were taken from the same arm in heparinized syringes at the sampling intervals and analyzed for blood gases, hematocrit, and percent sickle cells. Measurements of blood pressure, pulse, temperature, tidal volume, minute ventilation, and other significant data were recorded.