Cyclosporin A in experimental trichinosis scanning electron microscopic study.

The surface morphology of adult and larvae of Trichinella spiralis after cyclosporin A treatment was studied by scanning electron microscopy (SEM) of fixed, dried and metal coated specimens. The earliest topographic changes revealed in adults after the drug treatment were in form of disorganization of the cuticle especially between the hypodermal pores which appeared somewhat thickened and irregular. Other changes were in form of bullae formation covering the whole width of the adult surface.

Cyclosporin A in experimental trichinosis: histopathological study.

Cyclosporin A (CsA), a relatively new drug, was previously used in a series of studies on experimental trichinosis. This work was conducted to study the histopathological changes of CsA treatment at different time intervals from T. spiralis infection in mice.

Evaluation of enzyme-linked immunosorbent assay and counter-current immunoelectrophoresis in diagnosis of experimental trichinosis.

Definite diagnosis of trichinosisis mainly by direct demonstration of larvae, however, these methods are neither feasible nor sensitive. Thus, confirmation relies mainly on positive serology. In this study, enzyme-linked immunosorbent assay (ELISA) and counter-current immunoelectrophoresis (CIEP) using crude larval antigen were assessed as a tool in the diagnosis of trichinosis.

Immunization against Schistosoma mansoni by using Trichinella spiralis and Trichinella pseudospiralis antigens.

The antigenic fraction of a cell free homogenate of each of Trichinella spiralis and T. pseudospiralis were prepared to be used for induction of immunity against S. mansoni in albino mice.