Covalently Cross-Linked Polyelectrolyte Complex Nanoparticles with Enhanced Stability against Dissociation at High Ionic Strength.

Polyelectrolyte complex nanoparticles (PECNPs) often fully dissociate into individual polycations (PC) and polyanions (PA) at high salinities. Herein, we introduce a novel type of colloidally stable PECNP in which the PC is cross-linked, in this case branched polyethylenimine (PEI) to limit this dissociation, even in solutions up to 5.2 M NaCl or 5.

Fate and Transformation of 15 Classes of Per- and Polyfluoroalkyl Substances in Aqueous Film-Forming Foam (AFFF)-Amended Soil Microcosms.

The environmental fate of per- and polyfluoroalkyl substances (PFAS) in aqueous film-forming foams (AFFFs), especially those synthesized by electrochemical fluorination (ECF) processes, remains largely unknown. This study evaluated the transformation of AFFF-derived ECF-based precursors in aerobic soil microcosms amended with a historically used AFFF formulation (3M Light Water). Fifteen classes of PFAS, including AFFF components and transformation products, were identified or tentatively identified by suspect screening/nontargeted analysis (SSA/NTA) throughout a 308-day incubation.

Transport and competitive interfacial adsorption of PFOA and PFOS in unsaturated porous media: Experiments and modeling.

Among emerging contaminants, per- and polyfluoroalkyl substances (PFAS) have captured public attention based upon their environmental ubiquity and potential risks to human health. Due to their typical surface release conditions and amphiphilic properties, PFAS tend to sorb to soil and accumulate at the air-water interface within the vadose zone. These processes can result in substantial plume attenuation.

The cytidine deaminase APOBEC3A regulates nucleolar function to promote cell growth and ribosome biogenesis.

Cancer initiates as a consequence of genomic mutations and its subsequent progression relies in part on increased production of ribosomes to maintain high levels of protein synthesis for unchecked cell growth. Recently, cytidine deaminases have been uncovered as sources of mutagenesis in cancer. In an attempt to form a connection between these 2 cancer driving processes, we interrogated the cytidine deaminase family of proteins for potential roles in human ribosome biogenesis.