Publications by authors named "L Luostarinen"
Article Synopsis
- Low ferritin levels are commonly observed in patients with screen-detected coeliac disease, with 21% showing ferritin levels under 15 μg/L and 40% under 30 μg/L at diagnosis, despite being non-anaemic.
- After 1-2 years on a gluten-free diet (GFD), ferritin levels improved significantly from a median of 41.5 μg/L to 86.0 μg/L, yet 21% of patients still had ferritin levels under 30 μg/L.
- Interestingly, low ferritin levels didn't correlate with the severity of symptoms, quality of life, or other health indicators, suggesting that even though low ferritin is common in these patients
Aims: To explore if anti-gliadin antibody (AGA) positivity is associated with overall mortality or morbidity and especially with the development of coeliac disease during long-term gluten exposure.
Methods: The study population comprised 130 persistently AGA-positive but transglutaminase-2 (anti- TG2) -negative and 52 persistently AGA- and anti-TG2 -negative subjects aged 64-88 years. HLA-typing for DQ2 and DQ8 (coeliac-type HLA) was performed on the AGA-positives.
Background: Alemtuzumab is an effective disease-modifying therapy (DMT) for highly active multiple sclerosis (MS). However, safety concerns limit its use in clinical practice.
Objectives: To evaluate the safety of alemtuzumab in a nationwide cohort of Finnish MS patients.
Backround: Venous thromboembolism (VTE) after primary intracerebral hemorrhage (ICH) worsens patient prognosis. Administering low-molecular weight heparins (LMWH) to prevent VTE early (24 h) may increase the risk of hematoma enlargement, whereas administering late (72 h) after onset may decrease its effect on VTE prevention. The authors investigated when it is safe and effective to start LMWH in ICH patients.
View Article and Find Full Text PDFBackground: The revised paediatric criteria for coeliac disease allow omission of duodenal biopsies in symptomatic children who have specific serology and coeliac disease-associated genetics. It remains unclear whether this approach is also applicable for adults with various clinical presentations.
Aim: To evaluate the accuracy of serology-based criteria in adults with variable pre-test probabilities for coeliac disease.